Follow-up of patients click here affected by COVID-19 has unveiled remarkable findings.Among the several sequelae caused by SARS-CoV-2 viral infection, it is particularly noteworthy that patients are prone to developing depression, anxiety, cognitive disorders, and dementia as part of the post-COVID-19 syndrome.The multisystem aspects of this disease suggest that multiple mechanisms may converge towards post-infection clinical manifestations.The literature provides mechanistic hypotheses related to changes in classical neurotransmission evoked by SARS-CoV-2 infection; nonetheless, the interaction of peripherally originated classical and non-canonic peptidergic systems may play a putative role in this neuropathology.A wealth of robust findings shows that hemoglobin-derived peptides are able to equi-jec 6 control cognition, memory, anxiety, and depression through different mechanisms.
Early erythrocytic death is found during COVID-19, which would cause excess production of hemoglobin-derived peptides.Following from this premise, the present review sheds light on a possible involvement of hemoglobin-derived molecules in the COVID-19 pathophysiology by fostering neuroscientific evidence that supports the contribution of this non-canonic peptidergic pathway.This rationale may broaden knowledge beyond the currently available data, motivating further studies in the field and paving ways for novel laboratory tests and clinical approaches.